Are you using a free trial version of nero or a version you picked up somewhere or maybe Nero Kwik Burn?
I was thinking more of a basic burning software (imgburn gets good reports
http://www.imgburn.com/ ).
It's a little long winded but should be fairly foolproof and should confirm if the problem lies with the hardware or software.
Instructions here:
http://forum.imgburn.com/index.php?showtopic=5555Nero is very particular what it shares the PC with and it doesn't take much to throw it. I've downloaded a number of alternative programs in my time that have reduced Nero to being useless (and some of them quite expensive).
What OS are you using by the way? Windows 7? 32 or 64 bit and what are the specs.
Remember we are looking at several possible causes and the suggestions are to try to narrow it down for you.
Just as another thought, is there anything running in the background that could be using a lot of resources on the PC? You have done a virus scan I trust, just in case there's something nasty there.
Also think of any programs you may have installed just before it started acting like this.